DESCRIPTION
Amoxicillin and clavulanate belong to a class of drugs known as penicillin antibiotics, and are approved to treat a variety of bacterial infections including those that invade the ears, kidney, respiratory tract, sinuses, and skin. This drug stop the growth of bacteria that cause infection. Clavulanic acid is added to improve the efficacy of amoxicillin.

In combination amoxicillin and clavulanate have specific activity against penicillin-resistant organisms. Side effects include diarrhea, appetite loss, nausea, vomiting, stomach gas, and heartburn.

ORIGINAL USES (ON-LABEL)
Various bacterial infections.

NEWLY DISCOVERED USES (OFF-LABEL)
Diverticulitis, nocardiosis, peritonsillar abscess, tonsillectomy, tonsillitis.

POTENTIAL SIDE EFFECTS
Diarrhea, diaper and skin rash, urticaria, abdominal discomfort, nausea, vomiting, vaginitis, moniliasis.

CAUTIONS
  • Notify your doctor if you have an allergy to penicillins or cephalosporin antibiotics.
  • Dose and/or frequency of administration should be adjusted if you have kidney impairment.
  • Prolonged use of antibiotics may result in super-infection, resistance.
  • Do not use if you have a history of chole-static jaundice or hepatic dysfunction with amoxicillin-clavulanate.
  • A high percentage of patients with infectious mononucleosis have developed a rash during therapy.
  • The incidence of diarrhea is higher with amoxicillin-clavulanate than with amoxicillin alone.
  • Due to differing content of clavulanic acid, not all formulations are interchangeable.
  • Some products contain phenylalanine.
DRUG INTERACTIONS
Disulfiram, probenecid, allopurinol, warfarin, methotrexate, tetracyclines, chloramphenicol. If you are taking oral contraceptives, consult with your pharmacist or doctor.

FOOD INTERACTIONS
Unknown

HERBAL INTERACTIONS
Khat

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Amoxicillin is excreted into breast milk in low concentrations and is compatible. There is no human data pertaining to clavulanate and breast milk. Consult your doctor.

SPECIAL INFORMATION
Extended-release formulations should be taken with food. Two 250 mg tablets are not equivalent to a 500 mg tablet and two 500 mg tablets are not equivalent to a 1000 mg tablet in regards to amoxicillin. Some products contain phenylalanine.

A number of studies have evaluated amoxicillin and clavulanate for tonsillitis. In a study in Poland, the efficacy and safety of Augmentin were compared with another antibiotic drug, cefaclor. In this study, 100 children were treated with either Augmentin or cefaclor. This study showed that both antibiotic drugs provided nearly 98% efficacy; however, this drug was associated with more tonsillitis relapses and recurrences compared with cefaclor.

A study conducted in Greece found that five days of amoxicillin and clavulanate and clarithromycin (an antibiotic drug) were effective compared with penicillin 10-day treatment. However, this drug and penicillin were more effective against bacteria compared with clarithromycin, so researchers concluded that clarithromycin regimens should not be used to treat streptococcal tonsillitis.

Buy Augmentin online

Where can I buy Augmentin without prescription?
Amoxicillin/Clavulanate (Co-amoxiclav) is a prescription drug that comes in 375 mg, 625 mg, 1000 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell (Co-amoxiclav) without prescription. You may be able to order Augmentin from them online and save the local pharmacy markup.

Whether I can pay my order by Credit Card?
Drugstores accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

Is the Augmentin purchase legal?
Yes, it is legal. You confirm, that buy Augmentin tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Augmentin should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your order.

If I'm buying Augmentin online for the first time?
Buy Augmentin online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Augmentin at a reduced cost.

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What is Amoxicillin/Clavulanate?
Amoxicillin inhibits the production of the bacterial cell wall. Clavulanic acid helps amoxicillin expand its spectrum of activity.

What is Augmentin XR?
Augmentin XR contains the same antibiotic as Augmentin, but in a form that is released over time. The extended release of the medication helps kill some resistant bacteria that otherwise might continue to cause infection. Because Augmentin XR and Augmentin contain different proportions of clavulanate, which helps counteract resistance of the bacteria to antibiotics, it is not possible for your doctor to simply increase the recommended dose of Augmentin to achieve the same effect.
BRAND NAME
Augmentin ES-600, Augmentin XR, Augmentin

GENERIC NAME
Amoxicillin-Clavulanate

CHEMICAL CLASS
Penicillin derivative, aminopenicillin; beta-lactamase inhibitor (clavulanate)

THERAPEUTIC CLASS
Antibiotic (penicillin)
AVAIL FORMS
Amoxicillin/clavulanic acid tablets — Oral 375 mg (250/125 mg), 625 mg (500/125 mg), 1000 mg (875/125 mg)
DOSAGE
Adult
PO 250-500 mg (amoxicillin) q8h depending on severity of infection, 875 mg bid, or 2000 mg bid (XR)

Child 3 mo - 12 yr
PO 20-40 mg/kg/day (amoxicillin) in divided doses q8h; use chewable tablets under 40 kg for correct clavulanate dose; PO 90 mg/kg/d divided q12h (ES-600 suspension).

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