DESCRIPTION
Carisoprodol belongs to a class of drugs known as muscle relaxants. This drugs that reduce the tension in skeletal muscles. They are used to treat muscle spasms (involuntary and often painful contractions of muscles caused by injury or disease) and spasticity, in which the muscles are continually in a state of increased tension or rigidity due to such disorders as multiple sclerosis and cerebral palsy.
The muscle relaxants used in surgery during general anaesthesia work in a different way.
They act at neuromuscular junctions (where the nerve fibre meets the muscle it supplies) to block the transmission of nerve impulses, either by binding to receptor sites normally occupied by the chemical transmitter acetylcholine (nondepolarizing muscle relaxants, such as pancuronium and mivacurium ) or by mimicking the action of acetylcholine, making the muscle no longer receptive to stimulation by this transmitter (depolarizing muscle relaxants, such as suxamethonium).
ORIGINAL USES (ON-LABEL)
Relief of discomfort associated with acute, painful musculoskeletal conditions as an adjunct to rest, physical therapy, and other measures.
MECHANISM OF ACTION
Muscle relaxation by blocking interneuronal activity in the descending reticular formation and spinal cord; produces sedation
CONTRAINDICATIONS
Hypersensitivity (including related compounds such as meprobamate, mebutamate, or tybamate), child <12 yr, intermittent porphyria
PRECAUTIONS
Renal disease, hepatic disease, addictive personality, pregnancy (C), elderly, lactation
TREATMENT OF OVERDOSE
Induce emesis of conscious patient, lavage, dialysis
POTENTIAL SIDE EFFECTS
Drowsiness, dizziness, vertigo (avoid driving or activities that require alertness); dizziness when you get up or climb stairs (avoid sudden changes in position, use caution climbing stairs); nausea (take drug with food; eat frequent small meals); insomnia, headache, depression (transient effects).
CAUTIONS
- Abrupt cessation may precipitate mild withdrawal symptoms such as abdominal cramps, insomnia, chills, headache, and nausea.
- Carisoprodol should not be taken by people with porphyria or by breastfeeding women.
- It should be used with caution in those with liver or kidney disease or a history of drug or alcohol abuse and in pregnant women.
- Treatment should be stopped gradually.
- Decreased kidney function
- Decreased liver function
- Elderly people
- Epilepsy
- History of alcoholism or drug abuse
- Muscle weakness
DRUG INTERACTIONS
Tricyclics, opioids, barbiturates, sedatives, hypnotics.
FOOD INTERACTIONS
Avoid alcohol
HERBAL INTERACTIONS
Chamomile, kava, skullcap, valerian.
PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category C; crosses placenta; excreted in breast milk (2-4× maternal plasma)
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Carisoprodol is a prescription drug that comes in 350 mg pills.
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