Growth disorders may be caused by diseases of the kidneys, heart, gastrointestinal tract, lungs, bones, or other body systems. Other symptoms or physical signs in children with these illnesses usually give clues as to the disease causing the growth delay. However, poor growth may be the first sign of a problem in some of these conditions.
The predominant features of the McCune-Albright syndrome (MAS) occur in three areas: the bony skeleton, the skin, and the endocrine system. In all three systems, the extent of the abnormality and, in the case of the endocrine system, the nature of the abnormality, are highly variable from case to case, depending on the specific tissues involved and the extent of involvement. Although changes in ovary, bone, and skin tissue are most common, other endocrine and non-endocrine tissues also may be affected, including the adrenal, thyroid, pituitary, liver, and heart.
Commonly Prescribed (On-Label) Drugs: None
Off-Label Prescription Drugs Breakthrough Options: Anastrozole, Flutamide, Medroxyprogesterone Acetate, Pamidronate, Tamoxifen, Testolactone
Puberty is the period of physiological and anatomical development when the organs of sexual reproduction mature and become functional. This is not to be confused with adolescence, which is a socially defined period of psychological development that is sociocultural. In girls, the onset of menstruation and the development of the breasts mark this maturation. In boys, the biological markers of puberty are the enlargement of the external genitalia and the production of semen.
Two common puberty disorders are precocious and delayed puberty, which can develop in either boys or girls; however, treatment varies depending on the sex. boys or girls; however, treatment varies depending on the sex. Precocious puberty or “early puberty” is a condition in which the changes that normally accompany puberty, such as breast or genital development and growth of pubic hair, occur at an unexpectedly early age. Delayed puberty is defined as a condition in which a boy or girl has passed the usual age of the onset of puberty without develeoping any physical or hormonal signs that it is beginning. Delayed puberty may occur due to undernutrition as a symptom of a systemic disease, or due to abnormalities of the reproductive system (hypogonadism) or a response to sex hormones.
Commonly Prescribed (On-Label) Drugs: Histrelin, Leuprolide, Nafarelin, Testosterone
Off-Label Prescription Drugs Breakthrough Options: Letrozole, Medroxyprogesterone Acetate, Methylphenidate, Spironolactone and Testolactone in combination therapy
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