DESCRIPTIONDanazol is typically used for a variety of medical problems such as endometriosis, breast cysts, and abnormal swelling of the body tissues. Danocrine may also be used to treat gynecomastia since one of the more common side effects associated with its use is decreased breast size. Other side effects include flushing or redness of skin, mood or mental changes, and nervousness.
In a Korean review of medical records, the efficacy of danazol was compared with another drug, tamoxifen. In this analysis, researchers reviewed 68 men with gynecomastia. Twenty-three patients were treated with tamoxifen and 20 were treated with Danocrine. Complete resolution of gynecomastia was noted in 18 patients (78.2%) treated with tamoxifen and eight patients (40%) treated with danazol. In the tamoxifen group, five patients experienced gynecomastia recurrence. Researchers noted that although tamoxifen was more effective in reducing gynecomastia, it also resulted in a higher relapse rate.
British researchers at the Princess of Wales Royal Air Force Hospital examined the efficacy of danazol for gynecomastia in a comparison with placebo. In this study of 52 men, Danocrine reduced breast tenderness significantly more than placebo and was associated with a significant improvement in the degree of gynecomastia and breast size. A notable side effect with danazol treatment was weight gain. Researchers concluded that danazol provided effective control of gynecomastia and may eliminate the need for surgical breast reduction.
ORIGINAL USES (ON-LABEL)
Endometriosis, fibrocystic breast disease, and hereditary angioedema (recurrent allergic episodes which involve swelling of the skin, upper respiratory tract, and gastrointestinal tract).
NEWLY DISCOVERED USES (OFF-LABEL)
Autoimmune hemolytic anemia, dermatitis (chronic actinic), dysmenorrhea, gynecomastia, mastalgia, menorrhagia, menstrual migraine, premenstrual syndrome (PMS), therapy-resistant idiopathic thrombocytopenic purpura.
POTENTIAL SIDE EFFECTS
Acne, mild hair growth, hoarseness, weight gain, menstruation irregularities, flushing, sweating, liver dysfunction, vaginal dryness and irritation, emotional instability, reduction in breast size, changes in sperm count and motility.
CAUTIONS
- Not for use if you have undiagnosed abnormal genital bleeding, reduced liver, kidney, or heart function.
- Not for use in pregnancy or during breast-feeding. Pregnancy must be ruled out before starting this medication.
- Clot formation and life threatening of fatal stroke may occur with use of this medication.
- Use of this medication may result in serious liver events or serious high blood pressure.
- Before using for fibrocystic disease treatment, breast cancer should be ruled out.
- Use may increase the risk of certain cardiac disease, check with your doctor.
- Before using for fibrocystic disease, breast cancer must be excluded.
- Androgenic effects (masculinization) may not be reversible.
Tegretol, cyclosporine, tacrolimus, warfarin, statin drugs such as lovastatin, pravastatin, anti-diabetic drugs. Danazol may lessen the action of hormonal contraceptives (birth control); it is recommended that you use other, non-hormonal contraception during therapy.
FOOD INTERACTIONS
Take this drug on an empty stomach. Avoid high-fat meals unless instructed by doctor.
HERBAL INTERACTIONS
Unknown
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category X. Do not use in pregnancy or while breast-feeding.
SPECIAL INFORMATION
This drug has a black box warning regarding the risks of pregnancy, blood clots, long term therapy effects and high blood pressure related to increased pressure in the brain (benign intracranial hypertension). Pregnancy must be excluded as a possibility prior to initiation of therapy. During therapy a nonhormonal contraceptive method should be used. Report any signs and symptoms of intracranial hypertension to your doctor (such as headache, nausea, vomiting, vision changes.)
Buy Danazol online
Where can I buy Danazol without prescription?Danazol is a prescription drug that comes in 50 mg, 100 mg, 200 mg capsules. It is available on prescription only as capsules for oral use, but the online pharmacy, will sell Danocrine without prescription. You may be able to order Danazol from them online and save the local pharmacy markup.
Whether I can pay my Danocrine order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.
Is the Danocrine purchase legal?
Yes, it is legal. You confirm, that buy Danocrine capsules only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Danazol should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Danocrine order.
If I'm buying Danazol online for the first time?
If you are buying Danocrine without prescription for the first time, start with a small amount to make sure that it works for you and then order more later. Buy Danocrine online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Danazol at a reduced cost.
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What is Danazol?
This drug inhibits the release of hormones that are a part of the ovulation cycle. The decrease in the levels of these hormones results in a breakdown of endometrial tissue and also decreases the growth of abnormal breast tissue.
This drug inhibits the release of hormones that are a part of the ovulation cycle. The decrease in the levels of these hormones results in a breakdown of endometrial tissue and also decreases the growth of abnormal breast tissue.
BRAND NAME
Danocrine
GENERIC NAME
Danazol
CHEMICAL CLASS
Androgen; ethisterone derivative
THERAPEUTIC CLASS
Hormone (androgen)
Danocrine
GENERIC NAME
Danazol
CHEMICAL CLASS
Androgen; ethisterone derivative
THERAPEUTIC CLASS
Hormone (androgen)
AVAIL FORMS
Capsules — Oral 50 mg, 100 mg, 200 mg.
Capsules — Oral 50 mg, 100 mg, 200 mg.
DOSAGE
Adult
Endometriosis: PO initially 400 mg bid to achieve rapid response and amenorrhea; decrease to dose sufficient to maintain amenorrhea (100-200 mg bid) for 3-9 mo.
Fibrocystic breast disease: PO 100-400 mg/day in 2 divided doses.
Hereditary angioedema: PO initially 200 mg bid-tid; decrease dose by 50% or less at 1-3 mo intervals to lowest effective dose; if attack occurs, increase dose by up to 200 mg/day
Adult
Endometriosis: PO initially 400 mg bid to achieve rapid response and amenorrhea; decrease to dose sufficient to maintain amenorrhea (100-200 mg bid) for 3-9 mo.
Fibrocystic breast disease: PO 100-400 mg/day in 2 divided doses.
Hereditary angioedema: PO initially 200 mg bid-tid; decrease dose by 50% or less at 1-3 mo intervals to lowest effective dose; if attack occurs, increase dose by up to 200 mg/day
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