DESCRIPTION
Desogestrel ethinyl estradiol is used most commonly to prevent pregnancy or regulate the menstrual cycle. It may also be used for treating acne.

Acne and facial oiliness are related and affect a high proportion of women after their first menstrual bleeding. One of the treatment options is hormonal therapy, especially for women who require contraception. The effect of combined oral contraceptives in skin disorders depends on their estrogen-progestogen balance. The choice of product should be tailored as much as possible to the individual. Several combined oral contraceptives containing new-generation progestogens such as desogestrel have demonstrated efficacy in treating women with acne. Facial oil has been less well studied, but the few available studies show an improvement in women using combined oral contraceptives.

ORIGINAL USES (ON-LABEL)
Contraception

NEWLY DISCOVERED USES (OFF-LABEL)
Acne (women)

CONTRAINDICATIONS
Thrombophlebitis, thromboembolic disorders, history of deep vein thrombophlebitis, cerebrovascular disease, MI, CAD, known or suspected breast carcinoma or estrogen-dependent neoplasia, carcinoma of endometrium; hepatic adenomas, carcinomas; past or present angina pectoris, undiagnosed abnormal vaginal bleeding, cholestatic jaundice.

PRECAUTIONS
Hypertension, gallbladder disease, CHF, diabetes mellitus, depression, migraine headache, seizure disorders, hepatic disease, family history of breast or endometrial cancer, history of thromboembolic disorders, uterine fibroids, hypertriglyceridemia, hypercalcemia, cigarette smoking (especially >35 yr).

POTENTIAL SIDE EFFECTS
Depression, migraine headache, emotional lability. Arterial thromboembolism, pulmonary embolism, CVA, MI, hypertension, venous thrombosis edema. Contact lens intolerance, retinal thrombosis. Nausea and vomiting, gallbladder disease, bloating, benign hepatic tumors mesenteric thrombosis. Breakthrough bleeding (80% resolve in 3 mo), spotting, amenorrhea, change in cervical secretions, breast enlargement, breast tenderness. Hyperglycemia, hypertriglyceridemia, hypercalcemia, vitamin B-6 deficiency. Melasma.

CAUTIONS
  • Use drug with caution in patients with hypertension; convulsive disorders; migraines; asthma; cardiac, hepatic, or renal dysfunction.
  • Oral contraceptives may cause an increase in size of preexisting uterine leiomyomata (fibroids).
  • Some products may contain tartrazine, which may cause allergic-type reaction in susceptible individuals.
  • Acute intermittent porphyria. May be precipitated by estrogen therapy in susceptible individuals.
  • Use drug with caution in patients with history of depression.
DRUG INTERACTIONS
Warfarin, barbiturates, carbamazepine, griseofulvin, phenytoin, penicillins, rifampin; rifabutin, ritonavir, tetracyclines, corticosteroids, cyclosporine.

FOOD INTERACTIONS
Grapefruit juice (increased ethinyl estradiol concentration).

HERBAL INTERACTIONS
St. John's wort, dong quai, black cohosh, saw palmetto, red clover, ginseng

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category X. Do not use in pregnancy. Excreted in breast milk and not recommended during breast-feeding.

SPECIAL INFORMATION
  • Smoking: Increased risk of oral contraceptive-induced adverse cardiovascular events.
  • Give at same time each day. Efficacy depends on strict adherence to dosage schedule.
  • May be given with or without food.
  • Do not administer oral contraceptives to induce withdrawal bleeding as test for pregnancy.

    • Buy Apri online

    Where can I buy Apri without prescription?
    Desogestrel-ethinyl estradiol is a prescription drug that comes in 0.03 mg pills. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell contraceptive pills without prescription. You may be able to order Apri from them online and save the local pharmacy markup.

    Whether I can pay my order by Credit Card?
    Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.

    Is the Apri purchase legal?
    Yes, it is legal. You confirm, that buy Apri contraceptive pills only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Apri should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your order.

    If I'm buying Apri online for the first time?
    If you are buying contraceptive pills without prescription for the first time, start with a small amount to make sure that it works for you and then order more later. Buy Apri online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Apri at a reduced cost.

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    What is ?
    This drug inhibits ovulation by acting on the hypothalamus. Prevents secretion of two hormones important in the ovulation cycle: follicle stimulating hormone (FSH) and luteinizing hormone (LH).
    BRAND NAME
    Cyclessa, Desogen, Kariva, Mircette, Ortho-Cept, Apri

    GENERIC NAME
    Desogestrel/Ethinyl estradiol

    CHEMICAL CLASS
    Synthetic estrogen / progestin combinations

    THERAPEUTIC CLASS
    Oral Contraceptives
    AVAIL FORMS
    Tablets — Oral 0.03 mg ethinyl estradiol /0.15 mg desogestrel.
    DOSAGE
    Adult
    To achieve maximum contraceptive effectiveness, Apri (desogestrel and ethinyl estradiol) Tablets must be taken exactly as directed and at intervals not exceeding 24 hours. Apri tablets may be initiated using either a Sunday start or a Day 1 start.

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