DESCRIPTIONFluconazole is an oral antifungal medication that is used to treat a wide range of fungal diseases. Although a drug called amphotericin B is currently the FDA-approved drug to treat endophthalmitis caused by fungal infection, there are concerns about its potential to cause renal damage and the need to administer it by intravenous infusion, as reported in the Archives of the Spanish Society of Ophthalmology. Those risks are raised when it is given in conjunction with certain other drugs that the patient may be taking. In those instances, the physician may look to off-label anti-fungal drugs, such as fluconazole.
ORIGINAL USES (ON-LABEL)
Treatment of various fungal and yeast infections.
NEWLY DISCOVERED USES (OFF-LABEL)
Endophthalmitis
POTENTIAL SIDE EFFECTS
Headache, rash, nausea, vomiting, abdominal pain, diarrhea, upset stomach, taste perversion, serious skin reactions, liver toxicity.
CAUTIONS
- Do not take this drug at the same time as cisapride.
- Notify your doctor if you have impaired liver or kidney function or if you have developed liver problems while taking other antifungals.
- This drug has caused (rarely) serious problems with liver function or skin reactions and may require monitoring during multiple dose therapy. Notify your doctor immediately if you develop abdominal pain, jaundice (yellowing of skin), dark urine, or rash.
Rifampin, cisapride, amiodarone, selected benzodiazepines, calcium channel blockers, citalopram, cyclosporine, diazepam, ergot derivatives, fluoxetine, glimepiride, glipizide, statin drugs (such as lovastatin, atorvastatin, etc.), methsuximide, mirtazapine, nateglinide, nefazodone, phenytoin, pioglitazone, propranolol, rosiglitazone, sertraline, sildenafil, tadalafil, tacrolimus, venlafaxine, warfarin.
FOOD INTERACTIONS
May be taken with or without regard to food.
HERBAL INTERACTIONS
Unknown
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. Consult your doctor.
SPECIAL INFORMATION
This drug is often used as single dose therapy to treat some vaginal yeast infections.
The Spanish Society reported on the case of a patient with endophthalmitis due to the fungus Candida parapsilosis. The person was treated with amphotericin without success. Subsequently, the person was treated simultaneously with two off-label drugs - topical fluconazole and oral itraconazole - and they appeared to be effective in controlling the infection.
Additionally, oral fluconazole may be administered as reported by Indian researchers at the Joseph Eye hospital. They reported at a recent conference that in some cases oral fluconazole may be more effective than oral itraconazole because of its high water-soluble properties, which allow it to be absorbed into the body faster.
An earlier study reported in the Journal of Ocular Pharmacological Therapy had shown no retinal toxicity with Diflucan infusion and that it was effective in the treatment of experimental endophthalmitis due to the fungus candida.
Buy Diflucan online
Where can I buy Diflucan without prescription?Fluconazole is a prescription drug that comes in 50 mg, 100 mg, 150 mg, 200 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Fluconazole without prescription. You may be able to order Diflucan from them online and save the local pharmacy markup.
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Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.
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Yes, it is legal. You confirm, that buy Diflucan tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Fluconazole should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Fluconazole order.
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What is Fluconazole?
This drug interferes with the production of fungal cell membrane and inhibits cell membrane formation.
This drug interferes with the production of fungal cell membrane and inhibits cell membrane formation.
BRAND NAME
Diflucan
GENERIC NAME
Fluconazole
CHEMICAL CLASS
Triazole derivative
THERAPEUTIC CLASS
Antifungal
Diflucan
GENERIC NAME
Fluconazole
CHEMICAL CLASS
Triazole derivative
THERAPEUTIC CLASS
Antifungal
AVAIL FORMS
Tablets — Oral 50 mg, 100 mg, 150 mg, 200 mg.
Tablets — Oral 50 mg, 100 mg, 150 mg, 200 mg.
DOSAGE
Adult
Cryptococcal meningitis: PO / IV 400 mg on 1st day, then 200 mg qd for 10-12 wk after CSF becomes culture negative; increase up to 400 mg/day based on response.
Esophageal candidiasis: PO / IV 200 mg on 1st day, then 100 mg qd for at least 3 wk and for 2 wk following resolution of symptoms; doses up to 400 mg/day may be used based on response.
Oropharyngeal candidiasis: PO/ IV 200 mg on 1st day, then 100 mg qd for at least 2 week.
Other candidiasis: PO / IV 50-200 mg/day, doses up to 400 mg/day may be used based on response.
Prevention of candidiasis in bone marrow transplant: PO / IV 400 mg qd, initiate several days before anticipated onset of neutropenia, continue 7 days after neutrophil count rises above 1000 cells/mm3.
Vaginal candidiasis: PO 150 mg as a single dose.
Renal function impairment: PO / IV reduce dose by 50% in patients with CrCl <50 ml/min.
Child
Equivalent doses for children are 3 mg/kg for adult dose of 100 mg; 6 mg/kg - 200 mg; 12 mg/kg - 400 mg; do not exceed 600 mg dose.
Adult
Cryptococcal meningitis: PO / IV 400 mg on 1st day, then 200 mg qd for 10-12 wk after CSF becomes culture negative; increase up to 400 mg/day based on response.
Esophageal candidiasis: PO / IV 200 mg on 1st day, then 100 mg qd for at least 3 wk and for 2 wk following resolution of symptoms; doses up to 400 mg/day may be used based on response.
Oropharyngeal candidiasis: PO/ IV 200 mg on 1st day, then 100 mg qd for at least 2 week.
Other candidiasis: PO / IV 50-200 mg/day, doses up to 400 mg/day may be used based on response.
Prevention of candidiasis in bone marrow transplant: PO / IV 400 mg qd, initiate several days before anticipated onset of neutropenia, continue 7 days after neutrophil count rises above 1000 cells/mm3.
Vaginal candidiasis: PO 150 mg as a single dose.
Renal function impairment: PO / IV reduce dose by 50% in patients with CrCl <50 ml/min.
Child
Equivalent doses for children are 3 mg/kg for adult dose of 100 mg; 6 mg/kg - 200 mg; 12 mg/kg - 400 mg; do not exceed 600 mg dose.
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