Hemophilia is a bleeding disorder caused by a deficiency in one of the blood clotting factors. Hemophilia A (often called classic hemophilia) accounts for about 80% of all hemophilia cases. It is a deficiency in clotting factor VIII. Hemophilia A is a hereditary disorder in which the clotting ability of the blood is impaired and excessive bleeding results. Small wounds and punctures are usually not a problem, but uncontrolled internal bleeding can result in pain and swelling and permanent damage, especially to joints and muscles. Severity of symptoms can vary and severe forms become apparent early on.
Commonly Prescribed (On-Label) Drugs: Anti-Inhibitor Coagulant Complex, Antihemophilic Factor, Desmopressin, Factor IX, Factor VII, Tranexamic Acid
Off-Label Prescription Drug Breakthrough Option: Aminocaproic Acid
Hemostasis, the stopping of bleeding from an injured blood vessel, requires the process of several steps involving the constriction of blood vessels, platelets, and clotting actions. Hemostatic abnormalities can lead to excessive bleeding or thrombosis (clotting) when abnormalities occur in response to injury. This may reduce blood flow from trauma by local vasoconstriction (an immediate reaction to injury) and platelet factors cause platelets to adhere to the site of vessel wall injury and form aggregates or “plugs”.
Commonly Prescribed (On-Label) Drugs: None
Off-Label Prescription Drugs Breakthrough Options: Aprotinin, Desmopressin
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