DESCRIPTION
Isoniazid is used as first-line treatment and prevention of tuberculosis (TB) in combination with other drugs. It belongs to a large class of drugs, commonly called anti-infectives. TB is a highly contagious bacterial disease of the lung that is difficult to treat because the bacteria have become drug-resistant. Therefore, isoniazid treatment must be continued for six to 12 months, and some tuberculosis drugs may be taken up to two years. It is available in pill form, syrup, and injection. Patients with liver dysfunction and chronic alcoholism may not be able to take this drug as it can cause severe liver damage. Side effects include peripheral neuropathy, upset stomach, and hepatitis. Vitamin B-6 may be taken to decrease incidence of peripheral neuropathy (painful nerve damage), and to prevent gastrointestinal irritation.

ORIGINAL USES (ON-LABEL)
Treatment of susceptible and latent tuberculosis infections.

NEWLY DISCOVERED USES (OFF-LABEL)
Multiple sclerosis.

POTENTIAL SIDE EFFECTS
Loss of appetite, nausea, vomiting, stomach pain, increases in liver function tests, weakness, peripheral nerve pain, dizziness, slurred speech, lethargy, progressive liver damage, hyperreflexia.

CAUTIONS
  • Notify your doctor if you have acute liver disease or previous history of liver damage during isoniazid therapy.
  • Use caution if you have kidney impairment and chronic liver disease.
  • Severe and sometimes fatal liver toxicity may occur or develop even after many months of treatment.
  • Immediately report any of the following symptoms to your doctor, such as fatigue, weakness, malaise, anorexia, nausea, or vomiting.
  • Some patients may require concurrent pyridoxine therapy.
  • Periodic eye exams are recommended.
  • Dosage adjustment is necessary if you have liver impairment.
DRUG INTERACTIONS
Rifampin, acetaminophen, carbamazepine, chlorzoxazone, disulfiram, enflurane, phenytoin, ketoconazole, theophylline. This drug has the potential to interact with several drugs that are activated or cleared by the liver. As these are too numerous to list, you should always check with your doctor or pharmacist prior to starting a new medication, herbal, or nonprescription product.

FOOD INTERACTIONS
Avoid alcohol. May decrease folic acid absorption. Avoid foods containing tyramine (such as certain fish, tuna, etc.).

HERBAL INTERACTIONS
Unknown

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted into the breast milk and is probably compatible.

SPECIAL INFORMATION
Should be taken one hour before or two hours after meals on an empty stomach. This drug has a black box warning regarding the potential for severe and sometimes fatal hepatitis that may occur during and many months after treatment. Risk is related to age and increases with daily alcohol consumption. Monitoring of changes in liver function may be required at regular intervals. Report any signs of liver problems to your doctor immediately (such as dark urine, abdominal pain, yellowing discoloration of the skin and eyes, etc.).

Isoniazid treatment can help patients with Multiple Sclerosis, typically the related eye muscle disorders. In three case studies performed at a neurology clinic in Italy, three patients with MS with pendular nystagmus (involuntary rhythmic movement of the eyes) were treated. Two of the three patients experienced abolished and relieved oscillopsia (swinging vision). The third patient's eye recordings failed to show any effects on nystagmus, but visual acuity improved significantly. Nydrazid also helped cerebellar tremors found in patients with MS. Other treatments found effective in pendular nystagmus include valproic acid, trihexyphenidyl, and clonazepam. In other medical literature, isoniazid has been recommended in the treatment of vertigo and tremors in Multiple Sclerosis.

Buy Isoniazid online

Where can I buy Isoniazid without prescription?
Isoniazid is a prescription drug that comes in 300 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Nydrazid without prescription. You may be able to order Isoniazid from them online and save the local pharmacy markup.

Whether I can pay my Nydrazid order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

Is the Isoniazid purchase legal?
Yes, it is legal. You confirm, that buy Isoniazid tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Nydrazid should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Nydrazid order.

If I'm buying Isoniazid online for the first time?
Buy Nydrazid online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Nydrazid at a reduced cost.

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What is Nydrazid?
This drug acts against bacteria. It may work by the inhibition of mycolic acid production, resulting in disruption of the bacterial cell wall.
BRAND NAME
Nydrazid

GENERIC NAME
Isoniazid

CHEMICAL CLASS
Isonicotinic acid derivative

THERAPEUTIC CLASS
Antituberculosis agent
AVAIL FORMS
Tablets — Oral 300 mg.
DOSAGE
Adult
Treatment: PO or IM 5 mg/kg/day (up to 300 mg total) in a single dose; use in conjunction with other effective antituberculosis agents; duration of treatment 6 mo-2 yr.
Disseminated disease: PO 10 mg/kg/day in 1-2 divided doses.
Prophylaxis: PO or IM 300 mg qd.
Child
Treatment: PO or IM 10-20 mg/kg/day (up to 300 mg total) in 1-2 divided doses.
Prophylaxis: PO or IM 10 mg/kg/day qd, do not exceed 300 mg/day.

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