DESCRIPTIONKetoconazole interferes with the building of triglycerides and phospholipids in fungi, so the cell membrane is not made.
ORIGINAL USES (ON-LABEL)
Treatment of various systemic and skin fungal infections
NEWLY DISCOVERED USES (OFF-LABEL)
Cushing’s syndrome, hirsutism, hypercalciuria
POTENTIAL SIDE EFFECTS
Itching, nausea, abdominal pain, severe irritation, hair loss, abnormal hair texture, scalp pustules, and mild skin dryness.
CAUTIONS
- Do not use if you have fungal meningitis infections or with ergotamine type drugs, astemizole, lovastatin, midazolam, simvastatin, triazolam, and cisapride.
- Use with caution if you have impaired liver function; this drug may cause liver toxicity.
- High doses of ketoconazole may suppress adrenal gland function or the production of testosterone.
Ketoconazole tablets blocks a specific set of liver enzymes (cytochrome P450 enzymes) that are useful for the metabolism or promote the clearance of other drugs from the body. Ketoconazole interferes with these liver enzymes, and thus, may increase or decrease the clearance of these drugs from the body, often requiring dosage adjustments when they are administered in combination.
Amiodarone, amphetamines, benzodiazepines, beta-blockers, buspirone, busulfan, calcium channel blockers, cyclosporine, sirolimus, tacrolimus, digoxin, docetaxel, HMG-CoA reductase inhibitors (lovastatin, pravastatin, etc.), methylprednisolone, phenytoin, quinolones, trimetrexate, warfarin, sildenafil, tadalafil, vardenafil, and zolpidem. (This list is not comprehensive and you should check with your pharmacist for a complete listing). Carbamazepine, didanosine, isoniazid, phenobarbital, phenytoin, rifabutin, and rifampin, protease inhibitors.
Ketoconazole needs gastric acidity in the stomach to be absorbed. The use of antacids, histamine-2 blockers (such as cimetidine, ranitidine, famotidine) and proton pump inhibitors (such as omeprazole, pantoprazole, etc.) may reduce the extent of absorption by lessening the gastric acid production in the stomach. Give these products at least two hours after ketoconazole is taken.
FOOD INTERACTIONS
Avoid alcohol, may cause disulfiram-like reaction (flushing, sweating, increased heart rate, nausea, vomiting). Avoid alcohol ingestion for at least 48 hours after the last dose of ketoconazole.
HERBAL INTERACTIONS
St John's wort
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. It is not recommended for use in women who are breast-feeding.
SPECIAL INFORMATION
This drug has a black box warning regarding the possible adverse event of liver toxicity.
Monitoring of liver function should be performed during therapy. Take with food to minimize stomach upset.
This information pertains to the use of the prescription product only and should not be inferred for the use of nonprescription formulations.
Buy Nizoral online
Where can I buy Nizoral without prescription?Nizoral tablets is a prescription drug that comes in 200 mg tablets. It is available on prescription only as tablets for oral use, but the internet drugstore, will sell Nizoral without prescription. You may be able to order Nizoral from them online and save the local pharmacy markup.
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What is Nizoral?
Ketoconazole tablets are a powerful imidazole antifungal drug used for the treatment of fungal infections and to prevent fungal infections in those whose immune systems are functioning poorly (such as AIDS patients and the recipients of transplants). Ketoconazole (Nizoral) is particularly useful for treating resistant candidiasis (thrush), gastrointestinal infections, and infections of the skin, nails, and scalp.
Ketoconazole tablets are a powerful imidazole antifungal drug used for the treatment of fungal infections and to prevent fungal infections in those whose immune systems are functioning poorly (such as AIDS patients and the recipients of transplants). Ketoconazole (Nizoral) is particularly useful for treating resistant candidiasis (thrush), gastrointestinal infections, and infections of the skin, nails, and scalp.
BRAND NAME
Nizoral
GENERIC NAME
Ketoconazole
CHEMICAL CLASS
Imidazole derivative
THERAPEUTIC CLASS
Antifungal
Nizoral
GENERIC NAME
Ketoconazole
CHEMICAL CLASS
Imidazole derivative
THERAPEUTIC CLASS
Antifungal
AVAIL FORMS
Tablets — Oral 200 mg.
Tablets — Oral 200 mg.
DOSAGE
Adult
PO 200 mg qd initially, increase to 400 mg every day for serious infections or if clinical response insufficient; duration 1-2 week (candidiasis), 6 mo (other indicated systemic mycoses).
Child > 2 yr
PO 3.3-6.6 mg/kg/day as a single dose.
Adult
PO 200 mg qd initially, increase to 400 mg every day for serious infections or if clinical response insufficient; duration 1-2 week (candidiasis), 6 mo (other indicated systemic mycoses).
Child > 2 yr
PO 3.3-6.6 mg/kg/day as a single dose.
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