DESCRIPTION
Levonorgestrel and ethinyl estradiol belong to the class of medication known as oral contraceptives (OCs) or birth control pills, usually containing two types of hormones, estrogens and progestins. When these hormones are taken together they interfere with the normal hormonal fluctuations during the menstrual cycle and maintain them at a more constant level. This medication can also help reduce excessive production of androgens, body hair growth, acne and painful menstruation in polycystic ovary syndrome (PCOS).

Because the abnormal tissue in endometriosis is sensitive to menstrual cycle hormones, oral contraceptives are widely used to treat it and are often the first line of therapy for endometriosis. They can be given cyclically (three weeks on the pill and one week off) or continuously without interruption.

Levonorgestrel and ethinyl estradiol inhibits hormones and suppresses ovarian estrogen production. The endometrial tissue is reduced, and swelling, bleeding and inflammation decrease. This combination oral contraceptive has reduced pelvic pain and abnormal menstruation in up to 89% of patients. As with other hormonal therapy, there is no documented improvement in fertility. Oral contraceptives have been widely used in the United States for the past 40 years, and current estimates show that about 10 million American women use them annually.

ORIGINAL USES (ON-LABEL)
Prevention of pregnancy.

NEWLY DISCOVERED USES (OFF-LABEL)
Abnormal uterine bleeding, acne, dysmenorrhea, endometriosis, hirsutism, menopausal symptoms, menorrhagia, polycystic ovary syndrome.

POTENTIAL SIDE EFFECTS
Intermenstrual bleeding and irregularity, abdominal pain, diarrhea, nausea, vomiting, depression, dizziness, emotional lability, headache, migraine, nervousness, change in vision or ability to wear contact lenses, fluid retention, darkening of skin in areas, vaginal infections, hair loss. Increased risk of cardiac events, glucose intolerance, stroke, liver problems.

CAUTIONS
  • Oral contraceptives do not protect against sexually transmitted diseases or HIV infection.
  • Cardiovascular events increase if you are over 35 years of age and heavy smoker (at least 15 cigarettes daily), or have a history of cardiovascular disease or thromboembolic (blood clots) events.
  • Not for use if you have decreased kidney, adrenal or liver function, diabetes with vascular involvement, history of or suspected breast cancer or estrogen dependent cancer, undiagnosed genital bleeding, liver tumor, severe high blood pressure, jaundice associated with pregnancy or prior birth control pill usage, headaches with neurological symptoms.
  • Do not take if you are pregnant.
  • Discuss cardiac and other risks with your doctor prior to starting therapy.
DRUG INTERACTIONS
Oral contraceptives, including this product, may interact with several drugs too numerous to list. Check with your pharmacist or doctor before starting any new medication, herbal product, or nonprescription drug.

FOOD INTERACTIONS
Grapefruit juice

HERBAL INTERACTIONS
St. John's wort, dong quai, black cohosh, saw palmetto, red clover, ginseng.

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category X. Do not use in pregnancy. Excreted in breast milk and not recommended during breast-feeding.

SPECIAL INFORMATION
Read the patient information brochure prior to therapy for important instructions regarding therapy.

ALESSE AND POLYCYSTIC OVARY SYNDROME
Combination oral contraceptives are the most often used treatment for PCOS as they suppress androgen production, thus reducing skin androgenic symptoms and improving menstrual dysfunction. On the other hand, much still remains unknown about their metabolic effects. COCs could decrease insulin sensitivity and affect glucose tolerance, although the negative influence on insulin sensitivity is dependent on other factors (especially obesity) that may not be an issue if you are not obese. This impairment of glucose tolerance may be reversible, as the incidence of diabetes is not increased in past COC users. A study looked at whether a multi-drug that combines oral contraceptives and metformin is beneficial compared to COC alone. Altogether, 30 women in the study were randomly assigned to two groups treated with either COC (COC group) or COC and metformin (METOC group) for six months. Two dropped out. Investigators concluded that adding metformin slightly modified the effect of COC, causing a more significant decrease in testosterone. Researchers concluded that the available data does not offer enough evidence to advocate the standard use of combined treatment in PCOS, but the combination might be beneficial for specific subgroups.

Buy Alesse online

Where can I buy Alesse without prescription?
Levonorgestrel/Ethinyl Estradiol is a prescription drug that comes in 0.1 mg, 0.15 mg pills. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell it without prescription. You may be able to order Alesse from them online and save the local pharmacy markup.

Whether I can pay my Alesse order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.

Is the Alesse purchase legal?
Yes, it is legal. You confirm, that buy Alesse pills only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Alesse should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your order.

If I'm buying Alesse online for the first time?
If you are buying this drug without prescription for the first time, start with a small amount to make sure that it works for you and then order more later. Buy Alesse online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Alesse at a reduced cost.

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What is Alesse?
This drug inhibits ovulation. It prevents secretion of hormones important in the ovulation cycle: follicle stimulating hormone (FSH) and luteinizing hormone (LH). In addition, the cervical mucus of the vagina changes, becoming an environment hostile for sperm.
BRAND NAME
Levlen, Levora, Nordette, Portia, Seasonale, Alesse

GENERIC NAME
Levonorgestrel-Ethinyl Estradiol

CHEMICAL CLASS
Synthetic estrogen / progestin combinations

THERAPEUTIC CLASS
Contraceptive
AVAIL FORMS
Tablets — Oral 0.1 mg levonorgestrel/0.02 mg ethinyl estradiol, 0.15 mg/0.03 mg ethinyl estradiol.
DOSAGE
Adult
To achieve maximum contraceptive effectiveness, Alesse must be taken exactly as directed and at intervals not exceeding 24 hours.

Emergency contraception: 2 doses, 1st dose within 72 hr of unprotected intercourse; 2nd dose 12 hr later: Levonorgestrel 0.15 mg + ethinyl estradiol 30 µg: 4 tablets/dose

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