DESCRIPTIONMetoclopramide has a number of uses: it is a dopamine-receptor antagonist, an anti-emetic (drug that stops or prevents nausea and vomiting), and a stimulant of upper gastrointestinal (GI) activity. It is used in a wide variety of GI disorders, particularly gastroesophageal reflux disease (GERD), and to prevent chemotherapy-induced nausea and vomiting.
ORIGINAL USES (ON-LABEL)
Diabetic gastric stasis, gastroesophageal reflux disease (GERD).
NEWLY DISCOVERED USES (OFF-LABEL)
Hyperemesis gravidarum, migraine treatment, nephrogenic diabetes insipidus.
POTENTIAL SIDE EFFECTS
Restlessness, drowsiness, extrapyramidal symptoms (neurological side effects), diarrhea, weakness, rash, breast tenderness, nausea.
CAUTIONS
- Use in patients who have Parkinson’s disease or history of mental illness has been associated with extrapyramidal symptoms and depression. Extrapyramidal symptoms are characterized by involuntary movements of the limbs, facial grimacing, rhythmic protrusion of the tongue, etc.
- Extrapyramidal reactions typically occur within the first 24–48 hours of use and risk is higher in children and adults more than 30 years of age and at higher doses.
- Neuroleptic malignant syndrome (such as severe high blood pressure, tremors, etc.) has been reported (rare) with metoclopramide use.
- May cause transient elevations in serum aldosterone. Use with caution if you are at risk of fluid overload.
- Use caution if you have seizure history.
- Withdrawal symptoms may result (rare) upon abrupt discontinuation.
- Dose must be adjusted if you have kidney impairment.
Anticholinergics, antipsychotics, opiates, cimetidine, cyclosporine, levodopa, MAO inhibitors.
FOOD INTERACTIONS
Alcohol.
HERBAL INTERACTIONS
Unknown.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Excreted into breast milk. The American Academy of Pediatrics classifies metoclopramide as a drug for which the effect on a nursing infant is unknown but may be of concern.
SPECIAL INFORMATION
Immediately notify your doctor if involuntary movements of the eyes, face, or limbs occur. May produce drowsiness; use caution when performing tasks that require alertness. Take medication 30 minutes before meals.
Reglan has been successful in treating migraines. Experts have affirmed that it injected directly into the muscle may be considered as an add-on treatment to control nausea in people with acute migraine attacks; the IV formulation may be used alone to relieve migraine pain. Across the medical literature, metoclopramide hydrochloride has been identified as a possible option to treat and prevent nausea and vomiting, and to speed up the absorption of anti-migraine drugs.
In a study at the Albert Einstein College of Medicine in New York City, patients received IV metoclopramide hydrochloride alone or in combination with magnesium sulfate in the emergency room. Researchers unexpectedly found that the addition of magnesium to Reglan may reduce the effectiveness of metoclopramide in relieving migraine.
Buy Reglan
Where can I buy Reglan without prescription?Reglan medication is a prescription drug that comes in 10 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Reglan without prescription. You may be able to order Reglan from them online and save the local pharmacy markup.
Whether I can pay my Reglan order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.
Is the Reglan purchase legal?
Yes, it is legal. You confirm, that buy Metoclopramide tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Reglan drug should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Metoclopramide order.
If I'm buying Reglan online for the first time?
Buy generic Reglan online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you Metoclopramide drug at a reduced cost.
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What is Reglan?
Metoclopramide drug that antagonizes the action of dopamine. It is an antiemetic used to prevent or treat nausea and vomiting, including that produced by radiotherapy or cytotoxic chemotherapy for cancer, when it is usually given together with other drugs.
Metoclopramide drug that antagonizes the action of dopamine. It is an antiemetic used to prevent or treat nausea and vomiting, including that produced by radiotherapy or cytotoxic chemotherapy for cancer, when it is usually given together with other drugs.
BRAND NAME
Maxolon, Reglan
GENERIC NAME
Metoclopramide
CHEMICAL CLASS
Para-aminobenzoic acid derivative
THERAPEUTIC CLASS
Antiemetic; gastrointestinal prokinetic agent.
Maxolon, Reglan
GENERIC NAME
Metoclopramide
CHEMICAL CLASS
Para-aminobenzoic acid derivative
THERAPEUTIC CLASS
Antiemetic; gastrointestinal prokinetic agent.
AVAIL FORMS
Tablets — Oral 10 mg.
Tablets — Oral 10 mg.
DOSAGE
Adult
GERD / gastroparesis: PO 10-15 mg 30 min ac and hs.
Esophageal erosions and ulcerations: PO 15 mg qid as tolerated, healing documented in one controlled trial.
Child
GERD: PO 0.4-0.8 mg/kg/day divided qid.
Adult
GERD / gastroparesis: PO 10-15 mg 30 min ac and hs.
Esophageal erosions and ulcerations: PO 15 mg qid as tolerated, healing documented in one controlled trial.
Child
GERD: PO 0.4-0.8 mg/kg/day divided qid.
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