DESCRIPTION
Naproxen is an anti-inflammatory drug (NSAID) that also relieves pain and fever. It is used to relieve mild to moderately severe pain. NSAIDs reduce heavy menstrual bleeding when compared with placebo but are less effective than some of the other medications used for menorrhagia such as tranexamic acid or danazol. In the limited number of studies available, NSAIDs did not differ significantly in effectiveness compared to other treatments. However, there have been some reports of fewer side effects with NSAIDs.

Women who experience severe cramping may take naproxen 1 to 2 days before cramps begin. Naproxen improves physical symptoms and headache in women with PMS. Overall, NSAIDs may alleviate a wide range of symptoms except for breast pain.

ORIGINAL USES (ON-LABEL)
Management of inflammatory disease and rheumatoid disorders, acute gout, mild to moderate pain, dysmenorrhea, fever, migraine headache.

NEWLY DISCOVERED USES (OFF-LABEL)
Membranous nephropathy, menorrhagia, periodontitis, premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS).

POTENTIAL SIDE EFFECTS
Abdominal cramps, nausea, stomach upset, diarrhea, flatulence, weakness, stomach irritation, blurred vision, ringing in the ears, constipation.

CAUTIONS
  • Not for use if you are allergic to aspirin or other NSAIDs.
  • Not for use if you have active gastric/duodenal ulcer disease.
  • Do not use during third trimester of pregnancy.
  • Ask physician about use if you have any of the following medical problems: high blood pressure, dehydration, decreased kidney or liver function, history of gastric disease.
  • Elderly are at higher risk of developing side effects.
DRUG INTERACTIONS
Aspirin, lithium, methotrexate, digoxin, cyclosporine (nephrotoxicity), diuretics, some anti-hypertensives, and warfarin (bleeding). Other NSAIDs.

FOOD INTERACTIONS
Take with food to minimize upset stomach.

HERBAL INTERACTIONS
Cat's claw, dong quai, evening primrose, feverfew, garlic, ginger, ginkgo, red clover, horse chestnut, green tea, ginseng.

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B (D if in third trimester). Excreted in breast milk. Consult your doctor.

SPECIAL INFORMATION
Stop taking this drug (with doctor's approval) approximately 48 to 72 hours prior to surgical or dental procedures as it affects the body's ability to form blood clots and may increase bleeding time. In April 2005, the FDA announced the potential addition of a black box warning to the labeling of this class of drugs (NSAIDs), specifically regarding potential serious cardiac events and potentially life-threatening gastric adverse events.

In one study conducted in New Zealand, 45 ovulatory women with a complaint of menorrhagia were divided into three treatment groups. They received therapy with mefenamic acid in two cycles and one of three other agents in two cycles: naproxen, a low dose monophasic combined oral contraceptive, or low dose danazol. Mefenamic acid reduced measured blood loss by 20%; 38%; and 39% in groups one to three respectively. Naproxen reduced blood loss by 12%; the oral contraceptive by 43%; and danazol by 49%. There was no significant difference in blood loss reduction between any of the treatments, although women on danazol experienced a dramatic, highly significant further reduction in blood loss after the first treatment cycle.

Buy Naproxen online

Where can I buy Naproxen without prescription?
Naprosyn is a prescription drug that comes in 250 mg, 500 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Naprosyn without prescription. You may be able to order Naproxen from them online and save the local pharmacy markup.

Whether I can pay my Naprosyn order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

Is the Naproxen purchase legal?
Yes, it is legal. You confirm, that buy Naproxen tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Naproxen should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Naprosyn order.

If I'm buying Naproxen online for the first time?
Buy Naprosyn online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Naprosyn at a reduced cost.

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What is Naprosyn?
This drug inhibits prostaglandin synthesis by decreasing the activity of the enzyme responsible for the production of prostaglandins. Prostaglandins are a known mediator in the body of pain and inflammation.
BRAND NAME
Aleve, Anaprox (DS), EC-Naprosyn, Naprelan, Naprosyn

GENERIC NAME
Naproxen

CHEMICAL CLASS
Propionic acid derivative

THERAPEUTIC CLASS
Pain reliever, nonsteroidal anti-inflammatory [NSAID]; antipyretic; nonnarcotic analgesic
AVAIL FORMS
Tablets — Oral 250 mg, 500 mg.
DOSAGE
Adult
Arthritis: PO 250-500 mg (275-550 mg Naprosyn) bid, may increase to 1.5 g/day (1.65 g/day naproxen sodium) for limited periods; Sus Action PO 750-1000 mg qd; max 1000 mg/d.
Acute gout: PO 750 mg (825 mg Naprosyn), followed by 250 mg (275 mg naproxen sodium) q8h until attack subsides; Sus Action PO 1000 mg qd, may increase to 1500 mg qd for brief period if needed.
Mild to moderate pain, primary dysmenorrhea: PO 500 mg (550 mg naproxen sodium) at earliest symptoms of menses, followed by 250 mg (275 mg naproxen sodium) q6-8h; do not exceed 1.25 g/day (1.375 g/day Naprosyn).
Minor aches and pains (OTC): PO 220 mg q12h prn
Child
Juvenile arthritis: PO 10 mg/kg divided bid.

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