DESCRIPTION
Norgestrel-ethinyl estradiol is approved for use as a combination oral contraceptive medication. The combination oral contraceptive pill contains the hormones estrogen and progestogen. Ovral favored for treating endometriosis have a higher progestogen-to-estrogen ratio. Norgestrel-ethinyl estradiol may be useful off-label for women who have milder endometriosis symptoms, particularly adolescents and women who do not wish to take the other drugs available.

Continuously taking the combined oral birth control pill eliminates withdrawal bleeding and the incidence of period-related pain. It also reduces the amount of blood and the appearance of additional endometrial implants. Common side effects include fluid retention, nausea, breast tenderness, headaches, vaginal discharge and decreased sexual drive. Norgestrel-ethinyl estradiol is especially useful for minimizing the side effects of spotting and breakthrough bleeding.

ORIGINAL USES (ON-LABEL)
Prevention of pregnancy

NEWLY DISCOVERED USES (OFF-LABEL)
Abnormal uterine bleeding, amenorrhea, dysmenorrhea, endometriosis, hirsutism, menorrhagia, polycystic ovary

POTENTIAL SIDE EFFECTS
Include breast enlargement, fluid retention with a bloated feeling, weight gain, cramps and pains in the legs, headache, nausea, vomiting, depression, loss of libido, vaginal discharge, skin changes (including brown patches on the face), and breakthrough bleeding. There may be changes in libido, depression, an increase in blood pressure, and irritation from contact lenses. The occurrence of a migraine-like headache for the first time, frequent severe headaches, or visual disturbance should be reported immediately to a doctor.

CAUTIONS
  • Birth control pills should not be used during breastfeeding or by women with a history of thrombosis, heart disease, or angina, sickle-cell anaemia, a history of jaundice during pregnancy or any liver disease, breast or genital cancer, or undiagnosed vaginal bleeding; they should not be taken during pregnancy and must be stopped if pregnancy occurs.
  • The risk of thombosis is increased with age, smoking, and obesity. Breast examination should be carried out before and during treatment.
  • Birth control pills should be used with caution by women with high blood pressure, Raynaud's syndrome, diabetes, varicose veins, asthma, severe depression, or multiple sclerosis and by those on dialysis.
DRUG INTERACTIONS
Antiepileptic drugs (carbamazepine, phenobarbitone (phenobarbital), phenytoin, primidone, and topiramate), antifungal drugs (griseofulvin, fluconazole, itraconazole, and ketoconazole), modafinil, tretinoin, antiviral drugs, antibiotics (ampicillin, tetracycline, rifabutin, and rifampicin) can reduce the contraceptive effect of birth control pills.

FOOD INTERACTIONS
Grapefruit juice

HERBAL INTERACTIONS
St. John's wort, dong quai, black cohosh, saw palmetto, red clover, ginseng

PREGNANCY AND BREAST-FEEDING CAUTIONS
Pregnancy category X; may decrease quantity and quality of breast milk.

OVRAL IN TREATMENT OF DYSMENORRHEA
In order to determine the efficacy of oral contraceptives in the treatment of menstrual dysfunction 44 women with spasmodic dysmenorrhea, dysfunctional uterine bleeding, and menorrhagia (heavy bleeding) were treated with a norgestrel-ethinyl estradiol combination oral preparation. Those patients who were bleeding heavily at the time of examination received norgestrel and ethinyl estradiol three to four times daily until the bleeding stopped and then were maintained on one daily dose along with the other patients with less serious bleeding episodes until day 21 of treatment.

All 14 women with spasmodic dysmenorrhea had complete relief of symptoms and one case of primary infertility conceived after the therapy. The dysfunctional uterine bleeding group had similar results. Endometrial biopsies in the metropathic and menorrhagic patients revealed a return to normal endometrial function. The drug was extremely well tolerated in all patients with only two patients reporting minimum side effects. Researchers concluded that oral contraceptive preparations such as norgestrel-ethinyl estradiol are highly effective in the treating of menstrual dysfunction.

OVRAL AND UTERINE BLEEDINGS
To determine the efficacy of birth control pills in the treatment of menstrual disorders, 44 patients received a norgestrel-ethinyl estradiol combination oral preparation. The drug was extremely well tolerated in all patients: only two reported minimum side effects. Oral contraceptive preparations are highly effective in the therapeutic manipulation of menstrual function.

Treatment with Ovral tablets helps women with persistent uterine bleeding. Correction of the cause of bleeding is the first consideration when providing treatment. Estrogen-progestin combinations, such as norgestrel-ethinyl estradiol helped stop bleeding and stabilize the uterine tissues. Once an acute bleeding episode is controlled, additional treatment may be needed for several months. The dose of the oral combination contraceptive will be different for the acute and the long-term management of abnormal uterine bleeding.

Buy Ovral online

Where can I buy Ovral without prescription?
Norgestrel-Ethinyl Estradiol is a prescription drug that comes in 50 mcg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell it without prescription. You may be able to order Ovral from them online and save the local pharmacy markup.

Whether I can pay my order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, American Express (Amex), Wire transfers.

Is the Ovral purchase legal?
Yes, it is legal. You confirm, that buy Ovral tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Ovral should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your order.

If I'm buying Ovral online for the first time?
If you are buying contraceptive pills without prescription for the first time, start with a small amount to make sure that it works for you and then order more later. Buy birth control pills online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Ovral at a reduced cost.

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What is Ovral?
Norgestrel-ethinyl estradiol is a contraceptive containing estrogenic and progestinic steroids.
BRAND NAME
Cryselle, Lo/Ovral, Low-Ogestrel, Ogestrel, Ovral

GENERIC NAME
Norgestrel-Ethinyl Estradiol

CHEMICAL CLASS
Synthetic estrogen / progestin combinations

THERAPEUTIC CLASS
Contraceptive
AVAIL FORMS
Tablets — 50 mcg ethinyl estradiol/0.5 mg norethindrone.
DOSAGE
Adult
Sunday-Start Packaging: PO 1 tab daily beginning on first Sunday after menstruation begins. If menstruation begins on Sunday, take first tablet on that day.
21-day regimen: PO 1 tab daily for 21 days, beginning on day 5 of cycle. Take no tablets for 7 days; then start new course of 21-day regimen.
28-day regimen: PO 1 tab qd for 28 days.
Emergency contraception: 2 doses, 1st dose within 72 hr of unprotected intercourse; 2nd dose 12 hr later: Norgestrel 0.5 mg + ethinyl estradiol 50 µg: 2 tablets/dose

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