DESCRIPTIONThis drug inhibits the last step of gastric acid production by suppressing gastric acid secretion via the inhibition of a specific enzyme system in the stomach. This enzyme system is referred to as the acid (proton) pump in the stomach mucosa and this class of drugs is called the "proton pump inhibitors."
ORIGINAL USES (ON-LABEL)
Treatment of active duodenal ulcer disease, active benign gastric ulcer, gastroesophageal reflux disease (GERD), erosive esophagitis, hypersecretory conditions. Also used in combination with other drugs for the eradication of H. pylori in the stomach to reduce the risk of duodenal ulcer reoccurrence.
NEWLY DISCOVERED USES (OFF-LABEL)
Acute upper gastrointestinal (GI) bleeding, cystic fibrosis, prevention of upper gastrointestinal bleeding recurrence.
POTENTIAL SIDE EFFECTS
Headache, dizziness, diarrhea, abdominal pain, nausea, vomiting, constipation, rash, cough.
CAUTIONS
- Inform your doctor if you have allergies to any drugs in this class.
- Long-term treatment has resulted in atrophic gastritis.
- Absorption may be increased in the elderly.
- Zegerid use is contraindicated in patients with metabolic alkalosis and low calcium levels.
- Relief of symptoms with use of this drug does not exclude gastric cancer.
Benzodiazepines, carbamazepine, phenytoin, warfarin, amiodarone, citalopram, diazepam, fluoxetine, glimepiride, glipizide, methsuximide, nateglinide, phenytoin, pioglitazone, propranolol, rosiglitazone, sertraline, aminoglutethimide, rifampin, atazanavir, indinavir, itraconazole, ketoconazole, clarithromycin, sucralfate.
FOOD INTERACTIONS
Take before eating. Avoid alcohol.
HERBAL INTERACTIONS
St. John’s wort, ginkgo biloba.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. Therapy not recommended during breast-feeding.
SPECIAL INFORMATION
Swallow capsules whole, do not chew, open, or split.
An article in the International Journal of Clinical Practice from Hahnemann University in Philadelphia, reported on a study to assess the benefits of Prilosec versus ranitidine in the treatment of acute upper gastrointestinal bleeding. The diagnosis had been confirmed by endoscopy (a flexible tube inserted down the throat into the stomach so the doctor can see the inside of the stomach with a special camera). They divided 92 patients to take one of the two drugs. The patients all had ulcers of the stomach or the duodenum or erosive gastritis. Based on recurrence of bleeding, stabilization of the lesion by repeat endoscopy, and patients' length of stay in the intermediate medical care unit, the investigators concluded that Prilosec was more effective than ranitidine in the medical treatment of acute upper GI bleeding.
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What is omeprazole?
Omeprazole belongs to a class of drugs called proton pump inhibitors approved for treating ulcers, gastroesophageal reflux, and other conditions caused by excessive acid in the stomach. They completely block the production of stomach acid by shutting down a system in the stomach known as the proton pump.
Omeprazole belongs to a class of drugs called proton pump inhibitors approved for treating ulcers, gastroesophageal reflux, and other conditions caused by excessive acid in the stomach. They completely block the production of stomach acid by shutting down a system in the stomach known as the proton pump.
BRAND NAME
Prilosec
GENERIC NAME
Omeprazole
CHEMICAL CLASS
Benzimidazole derivative
THERAPEUTIC CLASS
Antiulcer agent; gastrointestinal antisecretory agent; Proton pump inhibitor.
Prilosec
GENERIC NAME
Omeprazole
CHEMICAL CLASS
Benzimidazole derivative
THERAPEUTIC CLASS
Antiulcer agent; gastrointestinal antisecretory agent; Proton pump inhibitor.
AVAIL FORMS
Capsules — Oral 10 mg, 20 mg, 40 mg.
Capsules — Oral 10 mg, 20 mg, 40 mg.
DOSAGE
Adult
Active duodenal ulcer: PO 20 mg qd for 4-8 wk.
H. Pylori: PO 20 mg bid in combination with clarithromycin 500 mg bid and amoxicillin 1 g bid for 10 days; if active ulcer present at initiation of therapy continue omeprazole 20 mg qd for additional 18 days (other regimens have also been used).
Gastric ulcer: PO 40 mg qd for 4-8 wk.
GERD: PO 20 mg qd for 4-8 wk.
Maintenance of healing in erosive esophagitis: 10-20 mg qd.
Pathological hypersecretory conditions: PO 60 mg qd initially, doses up to 120 mg tid have been administered (administer doses >80 mg/day in divided doses).
Adult
Active duodenal ulcer: PO 20 mg qd for 4-8 wk.
H. Pylori: PO 20 mg bid in combination with clarithromycin 500 mg bid and amoxicillin 1 g bid for 10 days; if active ulcer present at initiation of therapy continue omeprazole 20 mg qd for additional 18 days (other regimens have also been used).
Gastric ulcer: PO 40 mg qd for 4-8 wk.
GERD: PO 20 mg qd for 4-8 wk.
Maintenance of healing in erosive esophagitis: 10-20 mg qd.
Pathological hypersecretory conditions: PO 60 mg qd initially, doses up to 120 mg tid have been administered (administer doses >80 mg/day in divided doses).
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