DESCRIPTION
Orlistat is an anti-obesity drug normally prescribed to people to help them lose weight. It has well documented effectiveness in both weight reduction and maintenance of that weight loss. Further, weight loss with the use of orlistat has been associated with a decrease in obesity-related cardiovascular risk factors. Because type 2 diabetes most commonly occurs in people who are over 40 and overweight, and because the risk of type 2 declines when people lose weight, a drug that helps people lose weight can help prevent type 2 diabetes.

ORIGINAL USES (ON-LABEL)
Management of obesity

NEWLY DISCOVERED USES (OFF-LABEL)
Prevention in type 2 diabetes

POTENTIAL SIDE EFFECTS
Oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation, fecal incontinence, abdominal pain, gum disorder, diarrhea, nausea, rectal pain, tooth disorder, vomiting, rash, back pain, muscle aches, menstrual irregularity, influenza, ear infection, sleep disorder, urinary tract infection.

CAUTIONS
  • While taking this medication, you must comply with dietary guidelines as instructed by your doctor. Side effects may increase if a high fat diet is ingested.
  • Requires supplementation with fat soluble vitamins (A, D, E, and K) to ensure adequate nutrition.
  • Notify your doctor if you have a history of urinary or kidney stones.
  • If you are diabetic, this therapy may require a dosage adjustment in your diabetic medications.
DRUG INTERACTIONS
Warfarin, cyclosporine, fat-soluble vitamins, pravastatin

FOOD INTERACTIONS
Do not take with high fat diet.

HERBAL INTERACTIONS
Cholecalciferol, vitamin E, beta carotene, linoleic acid

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Excretion in breast milk unknown. Breast-feeding is not recommended during therapy.

SPECIAL INFORMATION
You should be on a nutritionally balanced, reduced calorie diet that contains approximately 30% of calories from fat. Daily intake of fat, carbohydrate, and protein should be distributed over the three main meals. Read patient brochure completely prior to starting therapy.

According to Diabetes and Metabolism, treatment with orlistat reduces the incidence of type 2 diabetes in people who already have impaired glucose tolerance. And in those who already have type 2 diabetes, it has enabled them to lower their required dose of metformin, sulfonylureas, and/or insulin. Of concern, because diabetes patients are at greater risk of cardiovascular disease, it was also noted that it helped reduce their total and LDL cholesterols and other lipid markers and decreased inflammation associated with heart attack risk.

In the Prevention of Diabetes in Obese Subjects study, orlistat reduced the incidence of diabetes from 9% to 6% compared to placebo, according to Diabetes Care. However, analysis of three other trials reported a nonsignificant reduction in the incidence of type 2 from 2% to 0.6% with orlistat, as reported in the Archives of Internal Medicine.

Nonetheless, a report in the Journal of the American Board of Family Practitioners noted the benefits of orlistat in helping prevent diabetes in obese patients.

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Orlistat is a prescription drug that comes in 120 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Orlistat without prescription. You may be able to order Xenical from them online and save the local pharmacy markup.

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Yes, it is legal. You confirm, that buy Xenical pills only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Xenical should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Xenical order.

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What is Orlistat?
This drug inhibits the absorption of dietary fats by inhibiting the activity of the enzyme responsible for breaking down fats into absorbable units. This drug acts in the stomach and small intestine.
BRAND NAME
Xenical

GENERIC NAME
Orlistat

CHEMICAL CLASS
Lipase inhibitor

THERAPEUTIC CLASS
Weight loss
AVAIL FORMS
Capsules — Oral 120 mg
DOSAGE
Adult and Child >12 yr
PO 120 mg tid with each meal containing fat (during or within 1 hour after the meal)

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