DESCRIPTION
Improves insulin resistance by hepatic glucose metabolism, insulin receptor kinase activity, insulin receptor phosphorylation.

ORIGINAL USES (ON-LABEL)
Type 2 Diabetes — monotherapy and combination therapy, combination therapy with sulfonylureas, metformin, or insulin are indicated when monotherapy with diet and exercise are inadequate for control.

NEWLY DISCOVERED USES (OFF-LABEL)
Prevention of cardiovascular disease in type 2 diabetes, prevention in type 2 diabetes.

POTENTIAL SIDE EFFECTS
Headache, tooth disorder, aggravated diabetes, sore throat, sinusitis, upper respiratory infection, edema, muscle aches, increases in HDL cholesterol, decreases in triglycerides, too low glucose levels, weight gain, anemia.

CAUTIONS
  • Active liver disease or elevated liver function tests.
  • Inform your doctor if you have a history of jaundice or liver disease, if you currently have anemia or edema, or certain types of cardiac disease (class III or class IV congestive heart failure).
  • May result in resumption of ovulation if you are premenopausal but not ovulating.
  • Requires periodic monitoring of liver function and blood glucose parameters.
  • May cause too low blood glucose levels.
  • There is a possibility of fluid retention leading to or exacerbating congestive heart failure with combined therapy of pioglitazone and insulin.
DRUG INTERACTIONS
Delavirdine, fluconazole, gemfibrozil, ketoconazole, nicardipine, NSAIDs, sulfonamides, itraconazole, carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, secobarbital, oral contraceptives, bile acid sequestrants.

FOOD INTERACTIONS
May take without regard to meals.

HERBAL INTERACTIONS
St. John's wort, chromium, garlic, gymnema

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excretion in the breast milk is unknown. Therapy not recommended for those who are breast-feeding.

SPECIAL INFORMATION
If you miss a dose, do not double the dose the next day. When used in combination with insulin or other oral antidiabetic drugs, the risk of developing too low blood glucose is possible. Discuss risks and signs and symptoms with your doctor. Immediately report to your doctor and development of sudden weight gain, swelling, shortness of breath, nausea, vomiting, abdominal pain, fatigue, dark urine, or jaundice.

Thiazolidinediones are a class of drugs approved to help lower blood sugar levels in the treatment of diabetes. The first of these drugs to be introduced was troglitazone, but it has been removed from the market because of hazards to the liver. The second generation drugs, pioglitazone and rosiglitazone, have been proven to be safe. Off-label, the drugs have been found to help prevent heart disease in people with type 2 diabetes.

The Diabetes Control and Complications Trial, sponsored by the National Institute of Health (NIH), showed that a greater than 50% lower risk of heart disease is one of the proven long-term benefits of tight glucose control in people with type 1 diabetes. This effect was achieved with insulin injections.

An article in Diabetic Medicine from the University of Turku, Finland, reported on the effects of rosiglitazone on heart glucose uptake in patients with type 2 diabetes, using placebo and metformin as control treatments. Researchers concluded that in addition to improving whole body insulin sensitivity, rosiglitazone enhances insulin stimulated myocardial glucose uptake.

A study in Diabetes, Obesity and Metabolism examined 172 adults with impaired glucose tolerance and insulin resistance who had been taking troglitazone. When it was taken off the market, 71 no longer took any glucose-lowering drug and became the control group; the other 101 were switched to either rosiglitazone or pioglitazone. After two years, none of the patients receiving either Avandia or Actos had developed diabetes, while 11 of the controls had done so; after another year, 3 of the patients taking either rosiglitazone or pioglitazone had developed diabetes and a total of 19 in the control group had done so. The incidence of diabetes was 88.9% lower in the rosiglitazone or pioglitazone group compared to controls.

Buy Actos online

Where can I buy Actos without prescription?
Pioglitazone is a prescription drug that comes in 15 mg, 30 mg tablets. It is available on prescription only as tablets for oral use, but the online pharmacy, will sell Pioglitazone without prescription. You may be able to order Actos from them online and save the local pharmacy markup.

Whether I can pay my Pioglitazone order by Credit Card?
Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.

Is the Actos purchase legal?
Yes, it is legal. You confirm, that buy Actos tablets only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Generic Pioglitazone should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Pioglitazone order.

If I'm buying Actos online for the first time?
Buy Pioglitazone online after comparing prices to your local pharmacy and you'll agree - any drugstore can sell you generic cheap Actos at a reduced cost.

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What is Actos?
Lowers blood sugar by improving response to insulin.
BRAND NAME
Actos

GENERIC NAME
Pioglitazone

CHEMICAL CLASS
Thiazolidinedione hypoglycemic

THERAPEUTIC CLASS
Antidiabetic, oral
AVAIL FORMS
Tablets — Oral 15 mg, 30 mg.
DOSAGE
Adult and Child >18 yr
PO 15-30 mg qd (maximum dose 45 mg/day)
Hepatic Impairment
Avoid use with concurrent liver dysfunction.

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