DESCRIPTIONThis drug inhibits the activation and promotion of T-lymphocytes, which can destroy target cells, and thus suppresses cellular immunity.
ORIGINAL USES (ON-LABEL)
Oral/injection: Prevention of rejection of liver or kidney transplantation.
Topical: Moderate to severe atopic dermatitis.
NEWLY DISCOVERED USES (OFF-LABEL)
Alopecia areata, blepharitis, dermatomyositis/polymyositis, keratoconjunctivitis sicca in graft vs. host disease, oral lichen planus, uveitis, varicella, vitiligo.
POTENTIAL SIDE EFFECTS
Oral, injection: Headache, tremor, insomnia, numbness, diarrhea, nausea, constipation, liver function tests, anorexia, vomiting, high blood pressure, kidney function, changes in potassium levels, increases in glucose, low magnesium levels, blood disorders (such as anemia, etc.), abdominal pain, pain, fever, ascites, peripheral edema, shortness of breath, itching, rash.
Topical: Headache, fever, skin burning, itching, redness, increased cough, flu-like symptoms, allergic reaction.
CAUTIONS
- Notify your doctor if you have an allergy to castor oil.
- Has caused post-transplant diabetes and may require monitoring. Also has been associated with nerve or kidney toxicity, particularly with high doses.
- Requires dose adjustment in kidney or liver impairment.
- Requires periodic monitoring during therapy with laboratory testing.
- May increase risk of infection.
Including but not limited to: potassium sparing diuretics (such as spironolactone, etc.), drugs which may cause kidney toxicity (such as amikacin, gentamicin, tobramycin, etc.), metoclopramide, antacids, calcium channel blockers (such as diltiazem, nicardipine, nifedipine, etc.), antifungal drugs (such as fluconazole, itraconazole, etc.), macrolides (such as clarithromycin, erythromycin, etc.).
This drug is metabolized by a specific set of liver enzymes. Several other drugs interfere with these liver enzymes, and thus may increase or decrease the clearance of tacrolimus from the body, potentially increasing the risk of side effects or decreasing effectiveness. When these drugs are given in combination with tacrolimus, dosage adjustments may be needed. As these are too numerous to list, you should always check with your doctor or pharmacist prior to starting a new medication, herbal, or nonprescription product.
FOOD INTERACTIONS
Avoid high fat meals and grapefruit juice.
HERBAL INTERACTIONS
St. John's wort.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excreted in breast milk. Do not use during breast-feeding.
SPECIAL INFORMATION
This drug has a black box warning regarding the risk of developing lymphoma when used as an immunosuppressant.
Buy Tacrolimus
Where can I buy Tacrolimus without prescription?Tacrolimus medication is a prescription drug that comes in 1 mg, 5 mg capsules. It is available on prescription only as capsules for oral use, but the drugstore, will sell Prograf without prescription online. You may be able to order Tacrolimus from them online and save the local pharmacy markup.
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Pharmacies accept credit cards Visa and Mastercard, online checks (ACH), EuroDebit, Wire transfers.
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Yes, it is legal. You confirm, that buy Prograf capsules only for personal use without the purposes of resale. All medicines are solved for application in the majority of the countries. Tacrolimus drug should pass any customs house, including American, without problems. If you have problems with customs house, inform pharmacy, they shall repeat (free-of-charge) your Prograf order.
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Buy generic Tacrolimus online after comparing prices to your local pharmacy and you'll agree - any pharmacy can sell you Prograf drug at a reduced cost.
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What is Tacrolimus?
Tacrolimus Capsules are an immunosuppressive drug that, in its oral form, is commonly used to prevent organ rejection in transplant patients.
Tacrolimus Capsules are an immunosuppressive drug that, in its oral form, is commonly used to prevent organ rejection in transplant patients.
BRAND NAME
Protopic, Prograf
GENERIC NAME
Tacrolimus
CHEMICAL CLASS
Macrolide derivative
THERAPEUTIC CLASS
Immunosuppressant
Protopic, Prograf
GENERIC NAME
Tacrolimus
CHEMICAL CLASS
Macrolide derivative
THERAPEUTIC CLASS
Immunosuppressant
AVAIL FORMS
Capsules — Oral 1 mg, 5 mg.
Capsules — Oral 1 mg, 5 mg.
DOSAGE
Adult
Liver transplant: PO 0.10-0.15 mg/kg/day in divided doses every 12 hours.
Kidney transplant: PO 0.2 mg/kg/day in divided doses q12h.
Renal or hepatic impairment: Initiate doses at low end of range; further reductions in dose may be required.
Adult
Liver transplant: PO 0.10-0.15 mg/kg/day in divided doses every 12 hours.
Kidney transplant: PO 0.2 mg/kg/day in divided doses q12h.
Renal or hepatic impairment: Initiate doses at low end of range; further reductions in dose may be required.
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