Miscarriage is defined by the absence of fetal breathing, heartbeats, pulsation of the umbilical cord, or definite movements of voluntary muscles. Early miscarriage occurs at less than 20 weeks of gestation. Intermediate miscarriage occurs at 20–27 weeks of gestation. Late miscarriage occurs at greater than 28 weeks of gestation.
An abortion is the expulsion or removal of an embryo or fetus from the mother prematurely. This can be done as an artificial procedure, but it often happens naturally when the mother’s body expels the fetus because of problems with the pregnancy. Medically induced abortions can be completed by a surgical procedure or treatment with special medications.
Commonly Prescribed (On-Label) Drugs: Carboprost, Dinoprost, Dinoprostone, Mifepristone, Oxytocin, Rho(D) Immune Globulin, Sodium Chloride
Off-Label Prescription Drugs Breakthrough Options: Mifepristone, Misoprostol, Methotrexate
An incomplete abortion is the clinical situation where part of the fetus or placental material is retained within the uterus. This can happen after a natural or medical abortion. Typical symptoms include vaginal bleeding and lower abdominal cramping. In most cases, a surgical intervention called curettage is performed to remove the remaining material from the uterus. The goal of this treatment is to prevent prolonged bleeding or infection.
Commonly Prescribed (On-Label) Drugs: Dinoprost
Off-Label Prescription Drugs Breakthrough Options: Carboprost, Methylergonovine, Misoprostol
Late abortion is defined as the termination of a pregnancy after the first trimester.
Commonly Prescribed (On-Label) Drugs: None
Off-Label Prescription Drugs Breakthrough Options: Mifepristone, Misoprostol
A missed abortion refers to a miscarriage where the fetus has died prior to 20 weeks of pregnancy, but neither the fetus nor the placenta has been expelled from the uterus and is retained in utero for two months or longer.
Commonly Prescribed (On-Label) Drugs: Dinoprostone Vaginal Suppositories
Off-Label Prescription Drug Breakthrough Option: Misoprostol
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