(za-FIR-loo-kast)

NEWLY DISCOVERED USES (OFF-LABEL)
Seasonal allergic rhinitis

ORIGINAL USES (ON-LABEL)
Prevention and chronic treatment of asthma

BRAND NAME
Accolate

DRUG CLASS
Asthma (leukotriene receptor antagonist)

DESCRIPTION
This drug relaxes the bronchial system, reduces inflammatory response in the lungs, and decreases hyper-responsiveness.

POTENTIAL SIDE EFFECTS
Headache, dizziness, nausea, diarrhea, abdominal pain, vomiting, upset stomach, hives, rashes, infection.

CAUTIONS
  • Not for use in the treatment of acute asthma attacks.
  • Patients older than 55 years appear to be at increased risk of developing infections during therapy.
  • Notify your doctor if you have liver impairment/disease.
  • Report any signs of possible liver toxicity during therapy, including right upper quadrant abdominal pain, nausea, fatigue, lethargy, jaundice, etc.
  • In rare instances, this drug has been associated with developing a blood disorder called eosinophilia.
DRUG INTERACTIONS
Aspirin, erythromycin, theophylline, warfarin

FOOD INTERACTIONS
Absorption decreased when taken with food. Take greater than one hour before or two hours after meals.

HERBAL INTERACTIONS
Unknown

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Excreted in breast milk. Do not breast-feed during therapy.

SPECIAL INFORMATION
Do not stop taking other anti-asthmatic drugs unless directed by physicians.

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