DESCRIPTION
Ziprasidone belongs to a class of drugs known as atypical antipsychotic drugs, used to treat the symptoms of schizophrenia, such as auditory or visual hallucinations, suspiciousness of others, mistaken beliefs (delusions), or withdrawal from normal activities. Side effects include constipation, mild dizziness, drowsiness, headache, nausea, vomiting, and upset stomach.
ORIGINAL USES (ON-LABEL)
Acute agitation in schizophrenia, manic episodes in bipolar disorders, schizophrenia.
NEWLY DISCOVERED USES (OFF-LABEL)
Autism, Gilles de la Tourette syndrome, Huntington's disease.
POTENTIAL SIDE EFFECTS
Drowsiness, headache, nausea, decreased heart rate, high blood pressure, increased heart rate, decrease in blood pressure upon abrupt standing from sitting or lying down position, dizziness, uncontrolled involuntary muscle movements, rash, skin reactions, painful menstruation, upset stomach, diarrhea, dry mouth, vomiting, pain at injection site, weakness, numbness, abnormal vision, respiratory disorder, rhinitis, cough increased, accidental injury, sweating, changes in heart rate (QT prolongation), changes in blood glucose (increases).
CAUTIONS
- This drug may cause changes in heart rhythm (prolonged QT interval). Not for use if you have a history of certain heart problems including prolonged QT, recent heart attacks, history of irregular heart rate, uncompensated heart failure, concurrent use of other QT prolonging medications.
- Immediately report symptoms of dizziness, sensations of increased heart rate, or fainting to your doctor.
- Use caution if you have Parkinson's disease due to the risk of extrapyramidal side effects (involuntary muscle movements).
- Notify your doctor if you have a history of seizures, are taking drugs which can lower seizure threshold. Inform your doctor if you are diabetic, have electrolyte imbalances, breast cancer, or other prolactin-dependent tumors.
- This drug may cause disturbances in temperature regulations and or neuroleptic malignant syndrome (NMS).
DRUG INTERACTIONS
Avoid combination
Antiarrhythmics (amiodarone, bretylium, disopyramide, dofetilide, encainide, flecainide, ibutilide, moricizine, procainamide, propafenone, quinidine, sotalol, tocainide).
Macrolide antibiotics (erythromycin, clarithromycin).
Phenothiazines.
Quinolone antibiotics (gatifloxacin, levofloxacin, moxifloxacin, sparfloxacin).
Tricyclic antidepressants.
Minimize risk
Carbamazepine: Added carbamazepine (induces CYP3A4) decreased AUC 35%; other inducers predicted to produce similar effects: barbiturates, oxcarbazepine, phenytoin, rifampin.
Ketoconazole: Added ketoconazole (inhibits CYP3A4) results in increased AUC and Cmax (35-40%); other inhibitors predicted to produce similar effects: cisapride, clarithromycin, erythromycin, fluconazole, itraconazole (all azole antifungals), quinine
Levodopa, dopamine agonists: Ziprasidone may antagonize the therapeutic effects of these drugs.
FOOD INTERACTIONS
Avoid alcohol, grapefruit juice.
HERBAL INTERACTIONS
St. John's wort, kava kava, chamomile.
PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category C. Excretion into breast milk is unknown. Refrain from breast-feeding while taking this drug.
SPECIAL INFORMATION
In 2005, the FDA published a safety alert that notified the public about an increased risk of death when atypical antipsychotics were used to treat behavioral disorders in elderly patients with dementia (unapproved use). The majority of deaths were attributed to cardiovascular events (such as heart failure or sudden death) or from infections (mostly pneumonia).
Researchers in Austria demonstrated that ziprasidone is useful in different stages of Huntington's disease (HD).
In one of these case studies, a 34-year-old woman with HD was unable to eat or dress without assistance.
She was given ziprasidone and her chorea symptoms visibly decreased and her gait and fine motor tasks also improved over a few days.
In the second case study, a 61-year-old man with Huntington's disease was successfully treated with ziprasidone. Improvement was seen as early as the next day after start of treatment.
In the third case study, a 42-year-old woman with HD was treated with ziprasidone and a clear improvement began two days after the start of treatment.
These studies show that this drug may be helpful in the treatment of chorea symptoms, since it does not impair fine motor tasks or gait as some typical antipsychotics do.
Buy Geodon online
Where can I buy Geodon without prescription?
Ziprasidone is a prescription drug that comes in 20 mg, 40 mg, 60 mg, 80 mg capsules.
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